ILC Research Reference List

The Lobular Breast Cancer Alliance has compiled a list of ILC research and studies related to lobular breast cancer.  The list includes studies from 2000 to the present.  We will update this research list periodically.  Suggestions for additions or changes to this list can be emailed to info@lobularbreastcancer.org for review.  Updated 05/24/2019

How to use this table: Use the headers on the columns to sort by category.   Use the Search function to locate specific study topics.   To read a full article with restricted access consult a local medical library or purchase access to the full article (LBCA can not send restricted articles due to license limitations).

Publications and Articles

NOTE:  Scroll left within the table for links to the full study or abstract.

AUTHORTITLEPUBLICATIONDATESTUDYGENERAL SUBJECTSPECIFIC SUBJECTLINK/PMC I.D.
AdachiComparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinomaBMC Cancer2016ClinicalClinico- pathologicalPrognosis
AnCdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the BreastCell Reports2018Basic/ TranslationalGenomicsLab Models
ArpinoInfiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcomeBreast Cancer Res2004ClinicalClinico- pathologicalPrognosis
ArthurMolecular Changes in Lobular Breast Cancers in Response to Endocrine TherapyCancer Res2014ClinicalGenomicsAnti-estrogen Therapy
BagliaAlcohol Intake and Risk of Breast Cancer by Histologic Subtype and Estrogen Receptor Status Among Women Aged 55 to 74 YearsHormones and Cancer2017EpidemiologyRisk FactorsAlcohol use
Barroso- SousaDifferences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implicationsAdv Med Onc2016ClinicalClinico- pathologicalTherapy Response/ Resistance
BergDiagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancerRadiology2004ClinicalImagingImaging Modalitieshttp://www.ncbi.nlm.nih.gov/pubmed/15486214
BuchananIs Pleomorphic Lobular Carcinoma Really a Distinct Clinical Entity?J Surg Oncol2008ClinicalClinico- pathologicalPleomorphichttp://www.ncbi.nlm.nih.gov/pubmed/28424130
CarcoforoInfiltrating Lobular Carcinoma of the Breast Presenting as Gastrointestinal Obstruction: A Mini ReviewJ Cancer2012ClinicalMetastasisGI Metastasishttp://www.jcancer.org/v03p0328.htm
ChenInvasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinomaPLOS One2017ClinicalClinico- pathologicalPrognosis
Chen21-gene recurrence score and adjuvant chemotherapy decisions in patients with invasive lobular breast cancerBiomark Med2018ClinicalGenomicsOncotype DX and Chemotherapyhttp://www.ncbi.nlm.nih.gov/pubmed/30565472
ChristgenLobular breast cancer: molecular basis, mouse and cellular modelsBreast Cancer Res2015Basic/ TranslationalCancer biologyLab Models
ChristgenLobular breast cancer: Clinical, molecular and morphological characteristicsPathology2016ClinicalCancer biology Pathologyhttp://www.ncbi.nlm.nih.gov/pubmed/27233940
ChristgenOncogenic PIK3CA Mutations in Lobular Breast Cancer ProgressionGenes Chrom Cancer2013ClinicalGenomicsPIK3CA Mutationshttp://www.ncbi.nlm.nih.gov/pubmed/22997091
ChristofanilliInvasive Lobular Carcinoma Classic Type: Response to Primary Chemotherapy and Survival OutcomesJ Clin Oncol2005ClinicalClinico- pathologicalChemotherapyhttp://www.ncbi.nlm.nih.gov/pubmed/15625359
CirielloComprehensive Molecular Portraits of Invasive Lobular Breast CancerCell2015Basic/ TranslationalGenomicsGenetic basis of ILChttp://doi.org/10.1016/j.cell.2015.09.033
ConlonIs There a Role for Oncotype Dx Testing in Invasive Lobular CarcinomaBreast J2015ClinicalGenomicsOncotype DX
CorsoCDH1 germline mutations and hereditary lobular breast cancer.Fam Cancer2016ClinicalHereditary breast cancerHereditary CDH1 mutationhttp://www.ncbi.nlm.nih.gov/pubmed/26759166/
CostarelliPleomorphic lobular carcinoma: is it more similar to a classic lobular cancer or to a high-grade ductal cancer?Breast Cancer2017ClinicalCancer biologyPleomorphichttp://www.ncbi.nlm.nih.gov/pubmed/29263698
DashevskyAppearance of untreated bone metastases from breast cancer on FDG PET/CT: Importance of histologic subtypeEur J Nucl Med Mol Imaging2015ClinicalImagingImaging-Bone Metastases
DelpechClinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomasBr J Cancer2013ClinicalClinico- pathologicalChemotherapy
DeniziatERBB2 mutations associated with solid variant of high-grade invasive lobular breast carcinomasOncotarget2016ClinicalGenomicsHER2
DesmedtGenomic Characterization of Primary Invasive Lobular Breast CancerJ Clin Oncol2016Basic/ TranslationalGenomicsGenetic basis of ILChttp://www.ncbi.nlm.nih.gov/pubmed/26926684
DesmedtESR1 mutations in metastatic lobular breast cancer patientsnpj Breast Cancer2019ClinicalGenomicsEstrogen receptor mutationhttp://www.nature.com/articles/s41523-019-0104-z
DesmedtImmune Infiltration in Invasive Lobular Breast CancerJ Natl Cancer Inst2018ClinicalCancer biologyImmunology
DitchiLow risk of invasive lobular carcinoma of the breast in carriers of BRCA1 and TP53 (Li-Fraumeni syndrome) germline mutationsBreast Journal2018ClinicalHereditary breast cancerHereditary BRCA1/2 and p53 mutationhttp://www.ncbi.nlm.nih.gov/pubmed/30414230
DixonInvasive lobular carcinoma: response to neoadjuvant letrozole therapyBreast Cancer Res Treat2011ClinicalClinico- pathologicalAnti-estrogen Therapyhttp://www.ncbi.nlm.nih.gov/pubmed/21870129
DossusLobular breast cancer: incidence and genetic and non-genetic risk factorsBreast Cancer Res2015ClinicalGenomicsRisk and Incidence
DuKey regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancerBreast Cancer Res2018Basic/ TranslationalCancer biologyAnti-estrogen resistancehttp://doi.org/10.1186/s13058-018-1041-8
EngstromInvasive lobular breast cancer: the prognostic impact of histopathological grade, E-cadherin and molecular subtypesHistopathology2015ClinicalClinico- pathologicalPrognosis
GainerInvasive Lobular Carcinoma Predicts Micrometastasis in Breast CancerJ Surg Res2012ClinicalCancer biologyMetastasis
Perez- GarciaEfficacy of Single-Agent Chemotherapy for Patients with Advanced Invasive LobularCarcinomaOncologist2018ClinicalClinico- pathologicalChemotherapyhttp://www.ncbi.nlm.nih.gov/pubmed/30578311
GatzaAnother Breast Cancer Entity Confirmed: Genomics of Invasive Lobular Breast CancerJ Clin Oncol2016CommentaryGenomicsGenomics of ILC
GuiuInvasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?Crit Rev Oncol Hematology2014ClinicalClinico- pathologicalTherapy Response/ Resistancehttp://www.ncbi.nlm.nih.gov/pubmed/25129506/
GuvenSentinel Lymph Node Metastasis in Invasive Lobular Carcinoma of the BreastEur J Breast Helath2018ClinicalMetastasisLymph node Metastasis
HaBreast MR Imaging before Surgery: Outcomes in Patients with Invasive Lobular Carcinoma by Using Propensity Score MatchingRadiology2018ClinicalImagingMRIhttp://www.ncbi.nlm.nih.gov/pubmed/29388904
HeDistant Metastatic Disease Manifestations in Infiltrating Lobular Carcinoma of the BreastAJR2014ClinicalMetastasisMetastatic Siteshttp://www.ncbi.nlm.nih.gov/pubmed/24758672
InoueSpecific sites of metastases in invasive lobular carcinoma: a retrospective cohort study of metastatic breast cancerBreast Cancer2017ClinicalMetastasisMetastatic Siteshttp://www.ncbi.nlm.nih.gov/pubmed/28108967
JacobsIssues Affecting the Loco-regional and Systemic Management of Patients with Invasive Lobular Carcinoma of the BreastBreast J2015ClinicalClinico- pathologicalTherapy Response and Resistancehttp://www.ncbi.nlm.nih.gov/pubmed/26782951
JohnsonLobular breast cancer series: imagingBreast Cancer Res2015ClinicalImagingImaging Modalitieshttp://doi.org/10.1186/s13058-015-0605-0
KatzPrimary systemic chemotherapy of invasive lobular carcinoma of the breastLancet2007ClinicalClinico- pathologicalChemotherapyhttp://www.ncbi.nlm.nih.gov/pubmed/17196511
LanglandsContralateral breast cancer: incidence according to ductal or lobular phenotype of the primaryClini Radiol2016ClinicalClinico- pathologicalContralateral Breast Cancerhttp://www.ncbi.nlm.nih.gov/pubmed/26703116
LiHormone replacement therapy in relation to risk of lobular and ductal breast carcinoma in middle-aged women.Cancer2000EpidemiologyRisk FactorsHormone Replacement Therapyhttp://www.ncbi.nlm.nih.gov/pubmed/10861435
LiChanging Incidence Rate of Invasive Lobular Breast Carcinoma among Older WomenCancer2000EpidemiologyRisk FactorsIncidencehttp://www.ncbi.nlm.nih.gov/pubmed/10861434
LiaoThe Clinicopathological Features and Survival Outcomes of Different Histological Subtypes in Triple-negative Breast CancerJ Cancer2018ClinicalClinico- pathologicalTriple-negative ILC
LoganMolecular drivers of lobular carcinoma in situBreast Cancer Res2015ClinicalCancer biologyLCIS
LokadasanMetastatic lobular carcinoma of breast mimics primary cervix carcinoma: two case reports and a review of the literatureecancer medicalscience2015ClinicalMetastasisCervical Metastasis
LopezInvasive Lobular Carcinoma of the Breast: Spectrum of Mammo- graphic, US, and MR Imaging FindingsRadiographics2009ClinicalImagingImaging Modalitieshttp://www.ncbi.nlm.nih.gov/pubmed/19168843
MamtaniLobular Breast Cancer Different Disease, Different AlgorithmsSurgical Oncol Cinics2018ClinicalGenomicsGenomics of ILChttp://www.ncbi.nlm.nih.gov/pubmed/29132567
MathewDistinct Pattern of Metastases in Patients with Invasive Lobular Carcinoma of the BreastGeburtshilfe Frauenheilkd2017ClinicalMetastasisMetastatic sites
MathieuThe poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profileEur J Cancer2004ClinicalClinico- pathologicalChemotherapyhttp://www.ncbi.nlm.nih.gov/pubmed/14746851
Metzger- FilhoMagnitude of trastuzumab benefit in patients with HER2-positive, invasive lobular breastcarcinoma: results from the HERA trialJ Clin Oncol2013ClinicalClinico- pathologicalHER2-targeted therapyhttp://www.ncbi.nlm.nih.gov/pubmed/23589556
Metzger- FilhoRelative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 TrialJ Clin Oncol2015ClinicalClinico- pathologicalAnti-estrogen Therapy
MontagnaLobular Metastatic Breast Cancer Patients With Gastrointestinal Involvement: Features and OutcomesClin Breast Cancer2018ClinicalMetastasisMetastatic siteshttp://www.ncbi.nlm.nih.gov/pubmed/28778379/
MukhtarBreast Conservation and Negative Margins in Invasive Lobular Carcinoma: The Impact of Oncoplastic Surgery and Shave Margins in 358 PatientsAnn Surgical Oncol2018ClinicalClinico- pathologicalSurgical methodshttp://www.ncbi.nlm.nih.gov/pubmed/30054826
NagleLoss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR InhibitorsClin Cancer Res2018Basic/ TranslationalCancer biologyCell signalinghttp://www.ncbi.nlm.nih.gov/pubmed/29941485
OesterreichOpening the Door for Immune Oncology Studies in Invasive Lobular Breast CancerJ Natl Cancer Inst.2018CommentaryCancer biologyImmunology
OliveraEvolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methodsInsights Imaging2014ClinicalImagingImaging modalities
OrvietoClinicopathologic characteristics of invasive lobular carcinoma of the breastCancer2008ClinicalClinico- pathologicalPrognosishttp://www.ncbi.nlm.nih.gov/pubmed/18704988
PatelValue Added of Preoperative Contrast-Enhanced Digital Mammography in Patients With Invasive Lobular Carcinoma of the BreastClinical Breast Cancer2018ClinicalImagingMammography methodshttp://www.ncbi.nlm.nih.gov/pubmed/30122347
PhalakSupplemental ultrasound screening in patients with a history of lobular neoplasiaThe Breast Journal2018ClinicalImagingImaging Modalitieshttp://www.ncbi.nlm.nih.gov/pubmed/30675929
PestalozziDistinct Clinical and Prognostic Features of Infiltrating Lobular Carcinoma of the Breast: Combined Results of 15 International clinical trialsJ Clin Oncol2008ClinicalClinico- pathologicalPrognosishttp://www.ncbi.nlm.nih.gov/pubmed/18458044/
RaapHigh frequency of lobular breast cancer in distant metastases to the orbitCancer Med2015ClinicalMetastasisOribital Metastasis
RakhaInvasive lobular carcinoma of the breast: response to hormonal therapy and outcomesEur J Cancer2008ClinicalClinico- pathologicalAnti-estrogen Therapyhttp://www.ncbi.nlm.nih.gov/pubmed/18035533/
ReedInvasive lobular carcinoma of the breast: morphology, biomarkers and ’omicsBreast Cancer Res2015ClinicalCancer biologyGenomics of ILC
ReedMixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphologyJ Pathology2018ClinicalCancer biologyMixed ductal-lobularhttp://www.ncbi.nlm.nih.gov/pubmed/29344954/
Rosa- RosaHigh Frequency of ERBB2 Activating Mutations in Invasive Lobular Breast Carcinoma with Pleomorphic FeaturesCancers2019ClinicalCancer biologyHER2 mutation/ Pleomorphichttp://www.mdpi.com/2072-6694/11/1/74/htm
RossRelapsed Classic E-Cadherin (CDH1)–Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene MutationsClin Cancer Res2013ClinicalGenomicsHER2 mutation/ ILC
SawyerGenetic Predisposition to In Situ and Invasive Lobular Carcinoma of the BreastPLOS2014EpidemiologyGenomicsGenetic Basis of ILC/LCIS
SelinkoRole of sonography in diagnosing and staging invasive lobular carcinomaJ Clin Ultrasound2004ClinicalImagingImaging Modalitieshttp://www.ncbi.nlm.nih.gov/pubmed/15293298
SengerInvasive lobular carcinoma of the male breast – a systematic review with an illustrative case studyBreast Cancer2017ClinicalClinico- pathologicalILC/ male patients
ShahPIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progressionBreast Cancer Res2017ClinicalGenomicsPIK3CA mutations/ LCIS
SikoraInvasive lobular carcinoma of the breast: Patient response to systemic endocrine therapy and hormone response in model systemsSteroids2012Basic/ TranslationalCancer biologyAnti-estrogen Therapyhttp://www.ncbi.nlm.nih.gov/pubmed/23178159
SikoraInvasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen responseCancer Res2014Basic/ TranslationalCancer biologyAnti-estrogen Therapy
SikoraWNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell linesBreast Cancer Res2016Basic/ TranslationalCancer biologyAnti-estrogen response and resistance
SingletaryTreatment Trends in Early-Stage Invasive Lobular CarcinomaAnn Surgery2005ClinicalClinico- pathologicalSurgical Methods
SledgeCollective Wisdom: Lobular Carcinoma of the BreastASCO2016ClinicalCancer biologyTherapy response/ resistance
SokolLoss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancerAnn Oncol2018Basic/ TranslationalGenomicsAnti-estrogen resistance
StangeHigh-Resolution Genomic Profiling Reveals Association of Chromosomal Aberrations on 1q and 16p with Histologic and Genetic Subgroups of IBC cell linesClin Cancer Res2006ClinicalGenomicsGenomics of ILC
Strasser- WeipplOutcomes in women with invasive ductal or invasive lobular early stage breast cancer treated with anastrozole or exemestaneEur J Cancer2018ClinicalClinico- pathologicalAnti-estrogen Therapyhttp://www.ncbi.nlm.nih.gov/pubmed/29274617
TeoE-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancerScientific Reports2018Basic/ TranslationalCancer biologyCell signaling
TasdemirComprehensive phenotypic characterization of human invasive lobular carcinoma cell lines in 2D and 3D culturesCancer Research2018Basic/ TranslationalCancer biologyLab models http://www.ncbi.nlm.nih.gov/pubmed/30228172
TruinDifferences in Response and Surgical Management with Neoadjuvant Chemotherapy in Invasive Lobular Versus Ductal Breast CancerAnnals of Surgical Oncol2016ClinicalClinico- pathologicalChemotherapy
UlanerProspective Clinical Trial of 18F-Fluciclovine PET/CT for Determining the Response to Neoadjuvant Therapy in IDC and ILCJournal of Nuclear Medicine2017ClinicalImaging18 F-Fluciclovine PET/CT
van de WaterInfluence of semi-quantitative oestrogen receptor expression on adjuvant endocrine therapy efficacy in ductal and lobular breast cancerEur J Cancer2012ClinicalClinico- pathologicalAnti-estrogen Therapyhttp://www.ncbi.nlm.nih.gov/pubmed/22954666
VargasPleomorphic lobular carcinoma of the breast: molecular pathology and clinical impactFuture Oncol2009ClinicalGenomicsPleomorphichttp://www.ncbi.nlm.nih.gov/pubmed/19284381
Venema18F-FES PET Has Added Value in Staging and Therapy Decision Making in Patients With Disseminated Lobular Breast Cancer.Clin Nucl Med2017ClinicalImagingFES PEThttp://www.ncbi.nlm.nih.gov/pubmed/28604479/
WinstonMetastatic Lobular Carcinoma of the Breast: Patterns of Spread in the Chest, Abdomen, and Pelvis on CTAJR2000ClinicalMetastasis Metastatic sites
WangThe Distribution and Outcomes of the 21-Gene Recurrence Score in T1-T2N0 Estrogen Receptor-Positive Breast Cancer With Different Histologic SubtypesFrontiers in Genetics2018ClinicalGenomicsOncotype DX
XiaoMixed invasive ductal and lobular carcinoma has distinct clinical features and predicts worse prognosis when stratified by estrogen receptor statusScientific Reports2017ClinicalClinico- pathologicalMixed IDC/ILC
XinA review of invasive lobular carcinoma of the breast: Should it be treated like invasive ductal carcinoma?Integr Cancer Sci Therapy2016ClinicalClinico- pathologicalPrognosishttp://www.oatext.com/pdf/ICST-3-211.pdf
YuClassical-type invasive lobular carcinoma with HER2 overexpression: clinical, histologic, and hormone receptor characteristicsAm J Clin Path2011ClinicalCancer biologyHER2 in ILChttp://www.ncbi.nlm.nih.gov/pubmed/21685036