ILC Publications Library

The Lobular Breast Cancer Alliance (LBCA) has compiled a reference list of research publications related to lobular breast cancer, also known as invasive lobular carcinoma (ILC).

With the addition of 19 new research articles in May, 2021, this list now includes 200 studies from 2000 to the present! Newly added studies are at the top of the table.

We update this research list periodically. Follow @LobularBCA and #lobular on Twitter to access up-to-date research.

How to use this table: Use the headers on the columns to sort by category. Use the Search function to locate specific study topics. To read a full article with restricted access consult a local medical library or purchase access to the full article. The LBCA can not send or link to restricted articles due to license limitations. Suggestions for additions or changes to this list can be emailed to for review. Patients utilizing this publications library are encouraged to discuss all studies with their providers.

This document was last updated May, 2021. 

Publications and Articles

AuthorTitlePublicationDateType of ArticleGeneral SubjectSpecific
AbelBreast conservation therapy versus mastectomy in the surgical management of invasive lobular carcinoma measuring 4 cm or greaterAmer J of Surgery2020RetrospectiveSurgeryPrognosis
BergeronTriple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutationsNature2021RetrospectiveGenomicsTriple-negative ILC
ChenSingle-Cell Transcriptomic
Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells
Cancer Res2021Lab ResearchCancer BiologyGenomics
HovisAccuracy of Preoperative Breast MRI versus Conventional Imaging in Measuring Pathologic Extent of Invasive Lobular CarcinomaJournal of Breast Imaging2021RetrospectiveImagingMRI
Invasive lobular
carcinoma of the breast: the increasing importance of this special subtype
Breast Cancer Res2021ReviewCancer BiologyGenomics and Pathology of ILC
overexpression of DNA repair genes in invasive ductal and lobular breast
carcinomas: Insights on individual variations and precision medicine
PLOS One2021RetrospectiveGenomicsDNA damage response
in Management Strategy and Impact of Neoadjuvant Therapy on Extent of Surgery
in Invasive Lobular Carcinoma of the Breast: Analysis of the National Cancer
Database (NCDB)
Annals of Surg Onc2021RetrospectiveSurgeryNeoadjuvent Therapy Response
Lobular Carcinoma of the Breast: Ongoing Trials, Challenges, and Future
Clinical Trials2021ReviewClinicopathologicalClinical Trials
review of molecular mechanisms and clinical features of invasive lobular
The Oncologist2021ReviewClinicopathologicalMolecular and clinical features
of ILC
alterations in invasive pleomorphic lobular carcinoma of the breast
Breast Cancer Res2021RetrospectiveGenomicsPleomorphic ILC
Value of EndoPredict in Women with Hormone Receptor-Positive, HER2-Negative
Invasive Lobular Breast Cancer
Clin Cancer Res2020RetrospectivePrognosisPrognostic Biomarkers
xenografts show lobular carcinoma cells rely on their own extracellular
matrix and LOXL1
Embo Molecular Med2021Lab ResearchCancer biologyTumor microenvironment
Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular
Carcinoma Cell Lines Requires WNT4
Cancers2020Lab ResearchCancer biologyEstrogen signaling
Outcomes of Total Skin-Sparing Mastectomy for Invasive Lobular Carcinoma of
the Breast: A 20-Year Institutional Experience
Ann Surg Onc2020RetrospectiveSurgerySurgical Methods
SottnickMediator of DNA damage
checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive
lobular carcinoma of the breast
Mol Cancer Res2021Lab ResearchCancer BiologyEstrogen Receptor
SumanAssociation of
variably methylated tumour DNA regions with overall survival for invasive
lobular breast cancer
Clin Epigenetics2021RetrospectiveGenomicsEpigenomics
of Adjuvant Chemotherapy in Patients with Lobular Breast Cancer: a Systematic
Review of the Literature and Metanalysis
Cancer Treatment Review2021ReviewClinicopathologicalTherapy Response
Van der
gene panel testing in lobular breast cancer
Familial Cancer2021RetrospectiveHereditary Breast CancerGermline (Herditary) Mutations
YangComparison of
Overall Survival Between Invasive Lobular Breast Carcinoma and Invasive
Ductal Breast Carcinoma: A Propensity Score Matching Study Based on SEER
Frontiers in Cancer2020RetrospectivePrognosisSurvival in ILC vs IDC
AbreuInvasive lobular
carcinoma: a rare presentation in the male breast
BMJ Case report2016Case ReportClinicopathologicalILC in Male patients
AdachiComparison of
clinical outcomes between luminal invasive ductal carcinoma and luminal
invasive lobular carcinoma
BMC Cancer2016RetrospectiveClinicopathologicalPrognosis
AdachiComparison of sentinel
lymph node biopsy between invasive lobular carcinoma and invasive ductal
Breast Cancer2018RetrospectiveSurgerySentinal Lymph Node biopsy
and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular
Carcinoma of the Breast
Cell Reports2018Laboratory ResearchGenomicsLab Models
lobular carcinoma of the breast: Should this be regarded as a chronic
Intl J Surg2010RetrospectiveClinicopathologicalPrognosis
lobular carcinoma of the breast: tumor characteristics and clinical outcome
Breast Cancer Research2004RetrospectiveClinicopathologicalPrognosis
Changes in Lobular Breast Cancers in Response to Endocrine Therapy
Cancer Res2014RetrospectiveGenomicsEndocrine Therapy
BaePreoperative MR
Imaging in Women with Breast Cancer Detected at Screening US
BagliaAlcohol Intake
and Risk of Breast Cancer by Histologic Subtype and Estrogen Receptor Status
Among Women Aged 55 to 74 Years
Hormones and Cancer2017RetrospectiveRisk FactorsAlcohol use
inhibitor synthetic lethality in breast cancer
Cancer Disc2018Lab ResearchCancer BiologyE-cadherin
between invasive lobular and invasive ductal carcinoma of the breast: results
and therapeutic implications
Adv Med Onc2016ReviewClinicopathologicalTherapy Response and Resistance
BergDiagnostic accuracy of
mammography, clinical examination, US, and MR imaging in preoperative
assessment of breast cancer
Radiology2004RetrospectiveImagingImaging Modalities
BergeronAn exceptional
metaplastic lobular breast carcinoma diagnosed through exome sequencing.
J Clin Path2020Case ReportGenomicsMetaplastic Carcinoma
BertozziPrevalence, risk
factors, and prognosis of peritoneal metastasis from breast cancer
Springer Plus2015RetrospectiveMetastasisPeritoneal Metastasis
treatment and outcome after breast cancer orbital and periorbital metastases:
a comprehensive case series including analysis of lobular versus ductal tumor
Breast Cancer Res2020RetrospectiveMetastasisOribital Metastasis
BrunerLoss of
E-Cadherin-Dependent Cell–Cell Adhesion and the Development and
Progression of Cancer
CSH Perspectives2018ReviewCancer BiologyE-cadherin
amplification in metastatic lymph-nodal and haematogenous lobular breast
J Exp Clin Cancer Res2012RetrospectiveGenomicsFGFR1 mutation
BuchananIs Pleomorphic Lobular
Carcinoma Really a Distinct Clinical Entity?
J Surg Oncol2008RetrospectiveClinicopathologicalPleomorphic ILC
CaoFrequent amplifications
of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma
Cancer Letter2019Lab ResearchCancer biologyGenomics
CarbogninTargeted next-generation
sequencing identifies genomic abnormalities potentially driving the prognosis
of early-stage invasive lobular breast carcinoma patients stratified
according to a validated clinico-pathological model.
Breast2020Lab ResearchGenomicsPrognosis
CarcoforoInfiltrating Lobular Carcinoma of
the Breast Presenting as Gastrointestinal Obstruction: A Mini Review
Journal of Cancer2012Case ReportMetastasisGI Metastasis
lobular carcinoma of the breast: A special histological type compared with
invasive ductal carcinoma
PLOS One2017RetrospectiveClinicopathologicalPrognosis
Chen21-gene recurrence score
and adjuvant chemotherapy decisions in patients with invasive lobular breast
Biomarkers in Medicine2018RetrospectiveGenomicsPrognostic Biomarkers
ChristgenLobular breast
cancer: molecular basis, mouse and cellular models
Breast Cancer Res2015ReviewCancer biologyLab Models
ChristgenLobular breast cancer:
Clinical, molecular and morphological characteristics
Pathology2016ReviewCancer biologyPathology
ChristgenOncogenic PIK3CA
Mutations in Lobular Breast Cancer Progression
Genes Chromosones Cancer2013RetrospectiveGenomicsPIK3CA Mutations
analysis in a lobular breast cancer with classical and solid growth pattern
mimicking a solid‐papillary carcinoma
J Patho Clin Res2017Case ReportGenomicsPapillary Carcinoma
impact of prognostic parameters in hormone receptor-positive lobular breast
Cancer2020RetrospectiveClinicopathologicalPrognostic Biomarkers
ChristofanilliInvasive Lobular
Carcinoma Classic Type: Response to Primary Chemotherapy and Survival
Journal of Clinical Oncology2005RetrospectiveClinicopathologicalChemotherapy
CirielloComprehensive Molecular
Portraits of Invasive Lobular Breast Cancer
Cell2015Lab ResearchGenomicsGenetic basis of ILC
lobular carcinoma of the breast: features associated with risk of late
distant recurrence
Breast Cancer Res2019RetrospectiveRisk FactorsLate Recurrence/Metastasis
CoronaManagement of the axilla
in breast cancer: outcome analysis in a series of ductal versus lobular
invasive cancers
Breast Cancer Res Treat2019RetrospectiveSurgeryLymph node metastasis
CorsoCDH1 germline mutations
and hereditary lobular breast cancer.
Fam Cancer2016ReviewHereditary breast cancerGermline CDH1 mutation
lobular carcinoma: is it more similar to a classic lobular cancer or to a
high-grade ductal cancer?
Breast Cancer2017RetrospectiveCancer biologyPleomorphic ILC
CrownIntraoperative radiation
therapy in early-stage breast cancer: Presence of lobular features is not
associated with increased rate of requiring additional therapy.
Am J Surg2019RetrospectiveSurgeryIntra-operative Radiation
Da RosHER2-positive lobular versus
ductal carcinoma of the breast: pattern of first recurrence and molecular
Clin Breast Cancer2018RetrospectiveClinicopathologicalHer2+ ILC
DabbsLobular versus ductal
breast neoplasms: the diagnostic utility of p120 catenin
Am J Surg Path2007RetrospectiveClinicopathologicalP120-Catenin
DaniaAssociations of
race and ethnicity with risk of developing invasive breast cancer after
lobular carcinoma in situ
Breast Cancer Res2019RetrospectiveRisk FactorsRace/Ethnicity
DashevskyAppearance of
untreated bone metastases from breast cancer on FDG PET/CT: Importance of
histologic subtype
J Nucl Med Mol Imaging
2015RetrospectiveImagingBone Metastases
de grootαE‐catenin
is a candidate tumor suppressor for the development of
E‐cadherin‐expressing lobular‐type breast cancer
J Pathology2018Lab ResearchCancer Biologye-cadherin
Adjuvant Chemotherapy in
Lobular Carcinoma of the Breast: A Clinicopathological Score Identifies
High-Risk Patient With Survival Benefit
Breast Cancer Res2019RetrospectiveClinicopathologicalChemotherapy
DelpechClinical benefit
from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal
and lobular carcinomas
British Journal of Cancer2013RetrospectiveClinicopathologicalChemotherapy
DeniziatERBB2 mutations
associated with solid variant of high-grade invasive lobular breast
Oncotarget2016RetrospectiveGenomicsERBB2(HER2) Somatic Mutations
inactivation of E-cadherin and p53 impairs functional gland development and
leads to pleomorphic invasive lobular carcinoma in mice
Dis Model Mech2011Lab ResearchCancer BiologyLab models of ILC
inactivation of E-cadherin and p53 in mice leads to metastatic lobular
mammary carcinoma through induction of anoikis resistance and angiogenesis
Cancer Cell2006Lab ResearchCancer BiologyLab models of ILC/Metastases
Characterization of Primary Invasive Lobular Breast Cancer
Journal of Clinical Oncology2016Lab ResearchGenomicsMutations in ILC
DesmedtESR1 mutations in
metastatic lobular breast cancer patients
npj Breast Cancer2019RetrospectiveGenomicsESR1 Mutation
Infiltration in Invasive Lobular Breast Cancer
J Natl Cancer Inst.2018RetrospectiveCancer biologyImmunology
lobular carcinoma of the breast: assessment of proliferative activity using
automated Ki-67 immunostaining
DiPiroLobular breast cancer:
patterns of intraabdominal metastatic spread on imaging and
Abdom Radiology2019RetrospectiveMetastasisAbdominal Metastasis
DitchiLow risk of
invasive lobular carcinoma of the breast in carriers of BRCA1 and TP53
(Li-Fraumeni syndrome) germline mutations
Breast Journal2018RetrospectiveHereditary breast cancerBRCA / p53 mutation
DixonInvasive lobular
carcinoma: response to neoadjuvant letrozole therapy
Breast Cancer Res Treat2011RetrospectiveClinicopathologicalEndocrine Resistance
DonaldsonBreast cancer risk
associated with atypical hyperplasia and lobular carcinoma in situ initially
diagnosed on core-needle biopsy
Cancer2018RetrospectiveRisk FactorsLCIS/Hyperplasia
DossusLobular breast
cancer: incidence and genetic and non-genetic risk factors
Breast Cancer Research2015ReviewRisk FactorsIncidence
DuKey regulators of lipid
metabolism drive endocrine resistance in invasive lobular breast cancer
Breast Cancer Research2018Lab ResearchCancer biologyEndocrine Resistance
EngstromInvasive lobular
breast cancer: the prognostic impact of histopathological grade, E-cadherin
and molecular subtypes
FeltsAn Analysis of Oncotype
DX Recurrence Scores and Clinicopathologic Characteristics in Invasive
Lobular Breast Cancer.
Breast j2017RetrospectiveGenomicsPrognostic Biomarkers
carcinomatosis in patients with breast cancer.
Crit Rev Oncol Hematol2019ReviewMetastasisLeptomeningal Metastasis
GainerInvasive Lobular
Carcinoma Predicts Micrometastasis in Breast Cancer
Journal or Surgical Research2012Lab ResearchCancer biologyMetastasis
GaoCDK4/6 inhibitor
treatment for patients with hormone receptor-positive, HER2-negative,
advanced or metastatic breast cancer
Lancet Oncol2019RetrospectiveClinicopathologicalCDK4/6 inhibitor response
immunohistochemical expression in invasive lobular carcinoma of the breast:
correlation with morphology and CDH1 somatic alterations
Human Pathology2020RetrospectiveClinicopathologicale-Cadherin/CDH1
GuiuInvasive lobular breast
cancer and its variants: how special are they for systemic therapy decisions?
Crit Rev Onco Hematology2014ReviewClinicopathologicalTherapy Response and Resistance
GuvenSentinel Lymph
Node Metastasis in Invasive Lobular Carcinoma of the Breast
European Journal Br Helath2018RetrospectiveMetastasisLymph Node Invasion
HaBreast MR Imaging
before Surgery: Outcomes in Patients with Invasive Lobular Carcinoma by Using
Propensity Score Matching
Diffuse Gastric Cancer Syndrome -CDH1 Mutations and Beyond
Jama Oncol2015RetrospectiveHereditary breast cancerHereditary CDH1 mutation
HarrellEstrogen induces
c-Kit and an aggressive phenotype in a model of invasive lobular breast
Oncogeniesis2017Lab ResearchCancer BiologyEstrogen signaling
HarrisonGenomic profiling of
pleomorphic and florid lobular carcinoma in situ reveals highly recurrent
ERBB2 and ERRB3 alterations
Mod Pathol2019RetrospectiveGenomicsERBB2 ,ERBB3/(Her2) Mutations
Metastatic Disease Manifestations in Infiltrating Lobular Carcinoma of the
AJR2014ReviewMetastasisMetastatic Sites
HoganComparison of
18F-FDG PET/CT for Systemic Staging of Newly Diagnosed Invasive Lobular
Carcinoma Versus Invasive Ductal Carcinoma
J Nucl Med2015RetrospectiveImagingFDG PET/CT
FOXO3-dependent transcriptional BMF activation underpins tumour growth and
metastasis of E-cadherin-negative breast cancer
Cell Death Diff2016Lab ResearchCancer BiologyMetastasis /E-cadherin
HoussamiMeta-analysis of
pre-operative magnetic resonance imaging (MRI) and surgical treatment for
breast cancer
Breast Canc Res Treat2017RetrospectiveImagingMRI
chemotherapy could not bring survival benefit to HR-positive, HER2-negative,
pT1b-c/N0–1/M0 invasive lobular carcinoma of the breast: a propensity
score matching study based on SEER database
BMC Cancer2020RetrospectiveClinicopathologicalChemotherapy
InoueSpecific sites of
metastases in invasive lobular carcinoma: a retrospective cohort study of
metastatic breast cancer
Breast Cancer2017RetrospectiveMetastasisMetastatic Sites
IorfidaInvasive lobular breast
cancer: subtypes and outcome
Breast Cancer Res Treat2012RetrospectiveClinicopathologicalPrognosis
lobular carcinoma in a male breast: a case report with review of the
Int J Clin Exp Pathol2013Case ReportClinicopathologicalMale ILC
JacobsIssues Affecting the
Loco-regional and Systemic Management of Patients with Invasive Lobular
Carcinoma of the Breast
The Breast Journal2015ReviewClinicopathologicalTherapy Response and Resistance
JohnsonLobular breast cancer
series: imaging
Breast Cancer Res2015ReviewImagingImaging Modalities
Metastasis from Breast Cancer: A Systematic Review
Cereus202ReviewClinicopathologicalBladder Metastasis
KatzPrimary systemic
chemotherapy of invasive lobular carcinoma of the breast
KizyImpact of the 21-gene
recurrence score on outcome in patients with invasive lobular carcinoma of
the breast
Breast Cancer Res2017RetrospectiveGenomicsPrognostic Biomarkers
KlarenbeekResponse of
metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly
mediated by the adaptive immune system
Oncoimmunology2020Lab ResearchCancer BiologymTor Inhibition
impact of lobular and ductal breast cancer histology on the metastatic
behavior and long term survival of breast cancer patients
The Breast2013RetrospectiveClinicopathologicalMetastasis
KurozumiTargetable ERBB2
mutation status is an independent marker of adverse prognosis in estrogen
receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a
retrospective in silico analysis of public datasets
Breast Cancer Research2020RetrospectiveCancer BiologyERBB2/Her2 mutations
KutasovicBreast cancer
metastasis to gynaecological organs: a clinico‐pathological and
molecular profiling study
J Pathol Clin Res2019RetrospectiveGenomicsGynocological Metastasis
LaenkholmPopulation-based Study of
Prosigna-PAM50 and Outcome Among Postmenopausal Women With Estrogen
Receptor-positive and HER2-negative Operable Invasive Lobular or Ductal
Breast Cancer.
Clin Breast Cancer2020RetrospectiveGenomicsPrognostic Biomarkers
LanglandsContralateral breast
cancer: incidence according to ductal or lobular phenotype of the primary
Clinical Radiology2016RetrospectiveClinicopathologicalContralateral Breast Cancer
overexpression and hotspot mutations in metastatic ER+ breast cancer are
enriched in the lobular subtype
NPJ Breast
2019Lab ResearchGenomicsMetastasis
LiHormone replacement
therapy in relation to risk of lobular and ductal breast carcinoma in
middle-aged women.
Cancer2000RetrospectiveRisk FactorsHormone Replacement Therapy
LiChanging Incidence Rate
of Invasive Lobular Breast Carcinoma among Older Women
Cancer2000RetrospectiveRisk FactorsIncidence
Clinicopathological Features and Survival Outcomes of Different Histological
Subtypes in Triple-negative Breast Cancer
J Cancer2018RetrospectiveClinicopathologicalTriple-negative ILC
LienFrequent alterations of
HER2 through mutation, amplification, or overexpression in pleomorphic
lobular carcinoma of the breast.
Breast Canc Res Treat2017RetrospectiveGenomicsHER2+ and mutations in PLC
drivers of lobular carcinoma in situ
Breast Cancer Res2015ReviewCancer biologyLCIS
lobular carcinoma of breast mimics primary cervix carcinoma: two case reports
and a review of the literature
ecancermedicalscience2015Case ReportMetastasisCervical Metastasis
LopezInvasive Lobular
Carcinoma of the Breast: Spectrum of Mammo- graphic, US, and MR Imaging
Radiographics2009ReviewImagingImaging modalities
Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic
Oncol and Therapy2019ReviewCancer BiologyGenomics and Therapy
MamtaniLobular Breast Cancer
Different Disease, Different Algorithms
Surgical Oncol Cinics2018ReviewClinicopathologicalGenomics of ILC
Histology Does Not Predict the Need for Axillary Dissection Among ACOSOG
Z0011-Eligible Breast Cancer
Ann Surg Oncol2019RetrospectiveSurgeryLymph Node Dissection
MannMRI compared to
conventional diagnostic work-up in the detection and evaluation of invasive
lobular carcinoma of the breast
Breast Cancer Res2008ReviewImagingMRI
Effectiveness of Adjuvant Chemotherapy for Invasive Lobular Compared With
Invasive Ductal Carcinoma of the Breast
MathewDistinct Pattern
of Metastases in Patients with Invasive Lobular Carcinoma of the Breast
Geburtshilfe Frauenheilkd2017RetrospectiveMetastasisMetastatic sites
MathieuThe poor responsiveness
of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be
explained by their biological profile
Eur J Cancer2004RetrospectiveClinicopathologicalChemotherapy
ductal-lobular carcinomas: evidence for progression from ductal to lobular
J Pathology2018RetrospectiveCancer biologyMixed ILC/IDC
LobSig is a
multigene predictor of outcome in invasive lobular carcinoma
NPJ Breast Cancer2019Lab ResearchGenomicsGene signatures
An epithelial to mesenchymal
transition programme does not usually drive the phenotype of invasive lobular
J Pathology2015Lab ResearchCancer BiologyE-Cadherin
Invasive lobular
carcinoma of the breast: morphology, biomarkers and Õomics
Breast Cancer Research2015ReviewCancer biologyGenomics
McLemoreBreast cancer:
presentation and intervention in women with gastrointestinal metastasis and
Ann Surg Onc2005RetrospectiveMetastasisGI Metastasis
Metzger-FilhoMagnitude of
trastuzumab benefit in patients with HER2-positive, invasive lobular breast
carcinoma: results from the HERA trial
Journal of Clinical Oncology2013RetrospectiveClinicopathologicalHER2+ ILC
Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular
Carcinoma in the BIG 1-98 Trial
Journal of Clinical Oncology2015RetrospectiveClinicopathologicalEndocrine Therapy
Metzger-FilhoGenomic grade adds
prognostic value in invasive lobular carcinoma
Ann Onc2013RetrospectiveGenomicsGene Signatures
Metzger-FilhoMixed Invasive
Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of
Histologic Grade
The Oncologist2018RetrospectiveClinicopathologicalMixed ILC/IDC
MichautIntegration of
genomic, transcriptomic and proteomic data identifies two biologically
distinct subtypes of invasive lobular breast cancer
Sci Rep2016Lab ResearchGenomicsGenetic basis of ILC
MontagnaLobular Metastatic
Breast Cancer Patients With Gastrointestinal Involvement: Features and
Clinical Breast Cancer2018RetrospectiveMetastasisMetastatic sites
MontanaghInvasive lobular
carcinoma with papillary features: A newly described variant that poses a
difficult histologic differential diagnosis.
Breast J2020Case ReportClinicopathologalPapillary Carcinoma
MotenCharacterizing lobular
carcinoma of the male breast using the SEER database.
J surg Res2013RetrospectiveClinicopathologicalMale ILC
MukhtarBreast Conservation and
Negative Margins in Invasive Lobular Carcinoma: The Impact of Oncoplastic
Surgery and Shave Margins in 358 Patients
Annals of Surgical Oncol2018RetrospectiveSurgerySurgical methods
MukhtarMitotic Score and
Pleomorphic Histology in Invasive Lobular Carcinoma of the Breast: Impact on
Disease-Free Survival
Breast Cancer Res Treat2020RetrospectiveClinicopathologicalPleomorphic ILC
NagleLoss of
E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast
Cancers to Anti-IGF1R/InsR Inhibitors
Clinical Cancer Research2018Laboratory ResearchCancer biologyCell signaling
NarbeThe Distribution of
Circulating Tumor Cells Is Different in Metastatic Lobular Compared to Ductal
Carcinoma of the Breast-Long-Term Prognostic Significance
Cells2020RetrospectiveMetastasisCirculating Tumor Cells
NarbeInvasive lobular
carcinoma of the breast: long-term prognostic value of Ki67 and histological
grade, alone and in combination with estrogen receptor
Springer Plus2014RetrospectiveClinicopathologicalPrognosis/Ki67
OesterreichOpening the
Door for Immune Oncology Studies in Invasive Lobular Breast Cancer
J Natl Cancer Inst.2018CommentaryCancer biologyImmunology
concepts in breast lobular neoplasia and invasive lobular carcinoma, and
their impact on imaging methods
Insights Imaging2014ReviewImagingImaging modalities
characteristics of invasive lobular carcinoma of the breast
PatelValue Added of
Preoperative Contrast-Enhanced Digital Mammography in Patients With Invasive
Lobular Carcinoma of the Breast
Clinical Breast Cancer2018RetrospectiveImagingMammography methods
Perez-GarciaEfficacy of Single-Agent
Chemotherapy for Patients with Advanced Invasive LobularCarcinoma
The Oncologist2018RetrospectiveClinicopathologicalChemotherapy
Clinical and Prognostic Features of Infiltrating Lobular Carcinoma of the
Breast: Combined Results of 15 International clinical trials
J Clin Oncol2008RetrospectiveClinicopathologicalPrognosis
PetridisFrequency of Pathogenic
Germline Variants in CDH1, BRCA2, CHEK2, PALB2, BRCA1, and TP53 in Sporadic
Lobular Breast Cancer
Cancer Epidemiol Biomark2019RetrospectiveGenomicsGenetic basis of ILC
PhalakSupplemental ultrasound
screening in patients with a history of lobular neoplasia
The Breast Journal2018RetrospectiveImagingLobular Neoplasia
RaapHigh frequency
of lobular breast cancer in distant metastases to the orbit
Cancer Med2015RetrospectiveMetastasisOribital Metastasis
RaapLobular carcinoma in
situ and invasive lobular breast cancer are characterized by enhanced
expression of transcription factor AP-2β.
Lab Invest2017Lab ResearchCancer BiologyGenomics of ILC
RakhaInvasive lobular
carcinoma of the breast: response to hormonal therapy and outcomes
Eur J Cancer2008RetrospectiveClinicopathologicalAdjuvent Endocrine Therapy
mediates Tamoxifen resistance in novel models of invasive lobular breast
Cancer Res2008Lab ResearchCancer biologyEndocrine Resistance
Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas
Clin Can Res2006RetrospectiveGenomicsFGFR1 mutation
Rosa-RosaHigh Frequency
of ERBB2 Activating Mutations in Invasive Lobular Breast Carcinoma with
Pleomorphic Features
Cancers2019RetrospectiveCancer biologyHer2(ERBB2) mutation in PLC
Classic E-Cadherin (CDH1)–Mutated Invasive Lobular Breast Cancer Shows
a High Frequency of HER2 (ERBB2) Gene Mutations
Clinical Cancer Research2013RetrospectiveGenomicsHER2(ERBB2) Mutation in iLC
SahinInvasive Pleomorphic
Lobular Histology Is an Adverse Prognostic Factor on Survival in Patients
with Breast Cancer
Am Surg2017RetrospectiveClinicopathologicalPleomorphic ILC
Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast
PLOS2014RetrospectiveGenomicsGenetic Basis of ILC/LCIS
p120-catenin regulates growth of metastatic lobular carcinoma through
Rock1-mediated anoikis resistance
J Clin Invest2011Lab ResearchCancer BiologyP120-Catenin
ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via
Distinct Mechanisms
Cancer Res2020Lab ResearchCancer BiologyLab Models
SelinkoRole of sonography in
diagnosing and staging invasive lobular carcinoma
J Clin Ultrasound2004RetrospectiveImagingImaging Methods
SengerInvasive lobular
carcinoma of the male breast – a systematic review with an illustrative
case study
Breast Cancer2017Case ReportClinicopathologicalMale ILC
ShahPIK3CA mutations
are common in lobular carcinoma in situ, but are not a biomarker of
Breast Cancer Res2017RetrospectiveGenomicsPIK3CA mutations in LCIS
ShamirGenetic analysis of
pleomorphic and florid lobular carcinoma in situ variants: frequent
ERBB2/ERBB3 alterations and clonal relationship to classic lobular carcinoma
in situ and invasivelobular carcinoma
Mod Pathol2020RetrospectiveGenomicsERBB2/3(Her2) mutation in
Pleomorphic and Florid LCIS/ILC
diffuse gastric cancer: association with lobular breast cancer
Fam Cancer2008Case ReportClinicopathologicalHerditary CDH1 mutation
SikoraInvasive lobular
carcinoma of the breast: Patient response to systemic endocrine therapy and
hormone response in model systems
Steroids2012ReviewCancer biologyEndocrine Resistance
SikoraInvasive lobular
carcinoma cell lines are characterized by unique estrogen-mediated gene
expression patterns and altered tamoxifen response
Cancer Resarch2014Lab ResearchCancer biologyEndocrine response and resistance
SikoraWNT4 mediates
estrogen receptor signaling and endocrine resistance in invasive lobular
carcinoma cell lines
Breast Cancer Res2016Lab ResearchCancer biologyEndocrine response and resistance
SingletaryTreatment Trends
in Early-Stage Invasive Lobular Carcinoma
Ann Surgery2005RetrospectiveSurgerySurgical Methods
Wisdom: Lobular Carcinoma of the Breast
ASCO2016ReviewCancer biologyTherapy response and resistance
SokolLoss of function
of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular
breast cancer
Ann Oncol2018Lab ResearchGenomicsEndocrine Resistance
regulation and targeting of estrogen receptor α turnover in invasive
lobular breast carcinoma
Endocrinology2020Lab ResearchCancer BiologyEndocrine Response (SERDS)
Genomic Profiling Reveals Association of Chromosomal Aberrations on 1q and
16p with Histologic and Genetic Subgroups of IBC cell lines
Clinical Cancer Research2006RetrospectiveGenomicsGenomics of ILC
Strasser-WeipplOutcomes in women with
invasive ductal or invasive lobular early stage breast cancer treated with
anastrozole or exemestane
European Journal of Cancer2018RetrospectiveClinicopathologicalEndocrine Therapy
Molecular Analysis of Tamoxifen-Resistant Invasive Lobular Breast Cancer
Cells Identifies MAPK and GRM/mGluR Signaling as Therapeutic Vulnerabilities
Mol Cell Endocrin2018Lab ResearchCell SignalingEndocrine Resistance
series of 21 patients with extrahepatic metastatic lobular breast carcinoma
to the gastrointestinal tract
Cancer Treat Comm2015Case ReportMetastasisGI Metastasis
lobular breast cancer. Prognostic significance of histological malignancy
Acta Onc2006RetrospectiveClinicopathologicalPrognosis
TamarisaThe impact of
chemotherapy sequence on survival in node-positive invasive lobular carcinoma
J Surg Onco2019RetrospectiveClinicopathologicalChemotherapy
phenotypic characterization of human invasive lobular carcinoma cell lines in
2D and 3D cultures
Cancer Resarch2018Lab ResearchCancer biologyLab models
Tenhagenp120-Catenin Is
Critical for the Development of Invasive Lobular Carcinoma in Mice
J Mamm Gland Biol Neo2016Lab ResearchCancer BiologyP120 Catenin
TeoE-cadherin loss
induces targetable autocrine activation of growth factor signalling in
lobular breast cancer
Scientific Reports2018Lab ResearchCancer biologyCell signaling
ThomasInvasive lobular breast
cancer: A review of pathogenesis, diagnosis, management, and future
directions of early stage disease
Semin Oncol2019ReviewClinicopathologicalNeoadjuvant Therapy
ThorntonNeoadjuvant Endocrine
Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular
Ann Surg Oncol2019RetrospectiveClinicopathologicalNeoadjuvent Therapy Response
lymphocytes are associated with poor prognosis in invasive lobular breast
Mod Pathol2020RetrospectiveCancer BiologyImmunology
TruinDifferences in
Response and Surgical Management with Neoadjuvant Chemotherapy in Invasive
Lobular Versus Ductal Breast Cancer
Annals of Surgical Oncol2016RetrospectiveClinicopathologicalNeoadjuvent Chemotherapy
UlanerProspective Clinical
Trial of 18F-Fluciclovine PET/CT for Determining the Response to Neoadjuvant
Therapy in IDC and ILC
Journal of Nuclear Medicine2017ProspectiveImaging18 F-Fluciclovine PET/CT
UlanerHead-to-head evaluation of
18F-FES and 18F-FDG PET/CT in metastatic invasive lobular breast cancer
J Nu Med2020ReviewImagingFES PET/CT
van de VenNuclear
p120-catenin regulates the anoikis resistance of mouse lobular breast cancer
cells through Kaiso-dependent Wnt11 expression
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